Infectious Disease Research

All fellows are expected to participate in a research project during the two-year program. A variety of opportunities are available in both basic science and clinical investigation. Some areas of particular interest at Mount Sinai are viral pathogenesis, HIV therapeutics, HPV screening, barriers to care in HIV and HCV, hospital epidemiology of resistant nosocomial pathogens, molecular epidemiology, and the prevention and management of infections in transplant recipients.

Select fellows are offered a third year of fellowship (non-ACGME). This fellowship year has protected research time with a focus on developing skills needed to become a successfully funded independent researcher.

Starting in the winter of the first year, research lunches are held to introduce ongoing research opportunities to the fellows. Fellows will also each be assigned a faculty advisor who meets with the fellow to discuss career and research interests.

It is expected that the fellow will identify a research interest and mentor and initiate preliminary work (i.e. IRB approval) on the project during the first year. The primary focus of the second year is completing the research project under the supervision of the mentor. Fellows who are interested in pursuing additional years of research training should discuss this option with their mentor and program director during the first year.

Before the end of the second year of fellowship, fellows are expected to submit research abstracts to a major infectious diseases meeting as well as present their work at our divisional grand rounds and our departmental research day. Ultimately, the research performed during fellowship should result in a manuscript for submission to a peer-reviewed journal.

Fellows interested in viral pathogenesis can pursue additional training in basic investigation through our NIH Training Grant in Viral Pathogenesis.

Fellows with an interest in clinical investigation can pursue a Master of Science in Clinical Research through the Clinical Research Training Program. Mount Sinai also has a Master of Public Health Program.


Research Opportunities

The Mount Sinai Health Care System provides fellows with a diverse array of research opportunities in basic science, translational and clinical research. In addition to opportunities within the Division of Infectious Diseases, our fellows have the chance to work on research collaborations with other Departments and Divisions, including Microbiology, Genomics, the Recanati Miller Transplant Institute, and Liver Medicine. The Infectious Disease Division has NIH funding for scientific research in viral pathogenesis and for research with the Clinical and Translational Research Center and the COVID Clinical Trials Unit. Additionally, the Center for Research on Influenza Pathogenesis is affiliated with our Division.

Our Researchers


Richard Silvera, MD, MPH

Assistant Associate Professor of Medicine

Dr. Silvera studies the use of genomics to identify anal cancers and precancers in people with HIV, identify lesions that are more likely recur after treatment, and develop better screening algorithms.

HPV, anal dysplasia, anal cancer

Benjamin K. Chen, MD, PhD

Professor of Medicine and Microbiology

The Chen laboratory studies HIV-1 pathogenesis and virus-immune system interactions to develop more effective treatment and prevention strategies.

HIV pathogenesis, Cell-to-cell transmission, Virological synapses, HIV-1 reservoir, Antibody responses, HIV-1 latency and cure, SARS CoV2 cell-cell transmission

Stephanie Factor, MD, MPH

Assistant Professor of Medicine

Dr. Factor’s research focuses on the epidemiology of emerging pathogens and the application of health informatics, artificial intelligence, and machine learning for infection prevention and nosocomial outbreak investigation.

Epidemiology, Emerging pathogens, Outbreak investigation, Health informatics, Artificial intelligence, and Machine learning

Caterina Hioe, PhD

Professor of Medicine and Microbiology

The Hioe laboratory studies HIV-envelope-mediated immunity and immune pathogenesis with the goal of developing preventive and therapeutic HIV vaccines.

HIV immunity, Immune pathogenesis, HIV vaccines

Sean Liu, MD, PhD

Assistant Professor of Medicine and Microbiology

Dr. Liu performs clinical trials on the management and prevention of the novel coronavirus (SARS-CoV2)

Clinical trials, Management and prevention of SARS-CoV2

Mary Jane Potash, PhD

Professor of Medicine and Microbiology

The Potash lab studies HIV replication and control using a re-constructed HIV to study the natural history of the virus with a mouse model.

HIV replication and control

Rebecca LR Powell, PhD

Assistant Professor of Medicine

Dr. Powell studies the role of antibody-dependent cellular phagocytosis (ADCP) in the low rates of HIV transmission through breast milk and the role of antibodies against SARS-CoV2 in breast milk as potential protection against COVID-19

Immunology of breast milk, HIV transmission, SARS-CoV2

Keith Sigel, MD, MPH, PhD

Associate Professor of Medicine

Dr. Sigel’s research focuses are the epidemiology, clinical management and outcomes for HIV and cancer and the outcomes of SARS-CoV2 infection in people living with HIV.

HIV and cancer, HIV and SARS-CoV2

Talia Swartz, MD, PhD

Associate Professor of Medicine and Microbiology

The Swartz lab has been focusing on the role of HIV in chronic inflammation and is studying the role of the NLRP3 inflammasome in the pathogenesis of severe COVID-19.

Chronic inflammation in HIV, pathogenesis of severe COVID-19 and the NLRP3 inflammasome

David Volsky, PhD

Professor of Medicine

The Volsky lab uses a genetically modified chimeric HIV that infects mice to study HIV pathogenesis, HIV neuropathogenesis, HIV reservoirs, HIV reactivation, anti-HIV immune responses and treatments.

HIV pathogenesis, HIV reactivation, HIV reservoirs in the central nervous system

Susan Zolla-Pazner, PhD

Professor of Medicine and Microbiology

The Zolla-Pazner lab studies the role of antibodies in the development of HIV vaccines, focusing on the role of humoral immunity as a preventive approach.

Humoral immunity, HIV vaccines and prevention

Alejandra Borjabad, PhD

Dr. Borjabad studies the genetic and epigenetic signatures and other molecular changes that define different neuropathologies in HIV-infection. More recently her research expanded to investigate other HIV pathogenic mechanisms like the contribution of glycomic dysregulation to neuroinflammation, the effect of HIV in animal models of Alzheimer’s disease and the effects of drug abuse including opioids, cocaine and CBD in the context of HIV infection.

HIV, neuropathology, cognitive impairment, genomics, epigenetics, CBD, drugs of abuse

Francesca Cossarini, MD

Assistant Professor of Medicine

Dr. Cossarini studies the immune cell changes induced by HIV in the intestinal tissue, their effect on systemic inflammation and the role of the gut as a reservoir for HIV infection

Mucosal immunology, HIV persistence, remission and cure

Eran Hadas, PhD

Assistant Professor of Medicine

Pending

Pending

Jennifer Kelschenbach, PhD

Assistant Professor of Medicine

Dr. Kelschenbach studies neuroimmune mechanisms involved in the development of HIV associated neurocognitive impairment in the context of substance use disorders using the EcoHIV mouse model.

HIV neurocognitive impairment, substance use disorder, neuroimmune interactions

Boe-Hyun Kim, PhD

Assistant Professor of Medicine

Dr. Kim studies the pathology, molecular virology, and potential therapy in the low HIV-infected brain using a murine HIV model.

Neurodegenerative Disorders in Infectious Diseases, HIV, NeuroAIDS, NeuroAging

Chitra Upadhyay, PhD

Assistant Professor of Medicine

Dr. Upadhyay’s research focuses on understanding HIV-1 envelope-mediated immunopathogenesis with the goal to inform the design and development of HIV-1 vaccines.

HIV-1 Envelope biogenesis, glycosylation and vaccine design

Contact Us

Samantha Crumbley

Program Manager

Division of Infectious Diseasessamantha.crumbley@mssm.edu

1 Gustave L. Levy Place Box 1090 New York, NY 10029 (212) 241-1117

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Our Fellows