Cardiology Research
The Zena and Michael A. Wiener Cardiovascular Institute is a swift conduit for the advancement of the art and science of cardiovascular medicine and surgery, enabling those with the spirit and ideas to fulfill their professional commitments to improving cardiovascular health. An academy for learning and for teaching, a laboratory for investigation and testing, a proving ground for the development and application of new technologies, the Cardiovascular Institute’s mission is to extinguish the spread of cardiovascular disease and replace it with a focus on health for our children and grandchildren. Our new insights into cardiovascular diseases have dramatically changed our thinking about the fundamental nature of heart disease and our approach to its prevention, diagnosis, and treatment. By integrating three corresponding disciplines — molecular cardiology, regenerative cardiology, and cardiac imaging — Icahn School of Medicine at Mount Sinai's Zena and Michael A. Wiener Cardiovascular Institute has made great headway in advancing research and developing new approaches to enhance patient care. As cardiovascular diseases have gained a larger foothold globally as the number one killer of people, Mount Sinai has been at the forefront of cardiovascular translational research thanks to the Zena and Michael A. Wiener Cardiovascular Institute. The Institute was created to more closely connect Mount Sinai's research advances with the clinical practice of medicine. The rapid translation of innovative research concepts into prevention, diagnosis, and therapy means that patients receive multidisciplinary treatment of unprecedented quality. Our programs span patient care from the earliest stages of life — our pediatric cardiologists can detect cardiac disease in the unborn fetus — well into advanced age through specialized geriatric cardiology. In 2006, the Zena and Michael A. Wiener Cardiovascular Institute dedicated to disease joined forces with the Marie-Josée and Henry R. Kravis Center for Cardiovascular Health at Mount Sinai dedicated to the promotion of health establishing what is today's Mount Sinai Heart. Today, the Cardiovascular Institute remains the leading translational research hub of Mount Sinai Heart.
A Commitment to Research
Year of Fellowship
Year 1
Year 2
Year 3
Year 4
Culture of Scholarship
Throughout Fellowship
- Dedicated time for research
- Dedicated biostatistician and IRB counselor
- Dedicated time/funding for fellows to attend ACC/AHA
- Quarterly newsletter on research and opportunities
- Bootcamp lectures on clinical trial design, epidemiology and biostatistics
- Conferences: CCU, cath, multimodality, journal club
- Presenters say how fellows can get involved in research
- Regular feedback on how to improve research experience
- Recruitment of junior faculty with research prowess
Personalized Mentorship
- Bootcamp showcases ongoing projects at MSH
- Hands-on matchmaking for fellows and project/mentors
- Design project proposal, acquire funding, IRB approval
- Guidance with submission of abstract to AHA/ACC
- Review drafts for publication
- Assistance applying for grant funding (eg. GRF, T32)
- Review drafts for publication
- Assistance with job applications; pathway to faculty positions
- A personalized, structured, and mentored research program with ample opportunities for funding under the supervision of world-renown leaders in cardiovascular research
Academic Productivity
- Controversies in Cardiology
- CCU, Cath Conferences
- Hurst's The Heart
- Present proposed project at research dinners early in year (new fellows also listen in)
- Cath conference, journal club
- Hurst's The Heart
- Formal presentation of research project
- Peer-reviewed publication
- Present at AHA/ACC
- Hurst's The Heart
The Cardiovascular Research Institute at Mount Sinai
The Cardiovascular Research Institute (CVRI) at the Icahn School of Medicine at Mount Sinai is a hub for fundamental and translational cardiovascular science. The Institute, which is located predominantly at the Leon and Norma Hess Research Building on Madison Avenue consists of over 12 laboratories performing research aimed at better understanding cardiovascular health and disease. Labs at the Institute use cardiology, vascular biology, molecular biology, immunology, hematology, and neuroscience approaches to elucidate fundamental mechanisms of atherosclerosis, myocardial infarction, myocarditis, and heart failure. The Institute offers a broad range of topics from understanding how lifestyle factors such as sleep, stress, or diet modulate the circulatory system to harnessing nanotechnology and genetic medicine for therapy.
Fellows at the CVRI will partner with a mentor and a senior fellow in a given lab (please see below for a list of the laboratories and their research focus). Over a period of 2 years, the fellow will work on a specific scientific project and will gain a deep understanding of the leading scientific concepts, the supporting literature, and key state-of-the-art technologies and approaches required to perform cutting edge and innovative science. The fellow will present their work at lab meetings and seminars, evaluate landmark papers at journal clubs, and meet leading scientists at Sinai and beyond. At the conclusion of the program, the fellow will be expected to make a significant contribution to scientific knowledge with a manuscript submitted to a leading scientific journal. The fellowship is designed to provide the fellow with the skills to become a successful NIH-funded physician-scientist at a leading research institution.
For more information about the CVRI please visit The Cardiovascular Research Institute at Mount Sinai.
If you are interested in the physician-scientist program within the fellowship, click here to complete the application.
A Selection of Impactful Publications by Our Fellows
Time Delay, Infarct Size, and Microvascular Obstruction After Primary Percutaneous Coronary Intervention for ST-Segment-Elevation Myocardial Infarction.Redfors B, Mohebi R, Giustino G, Chen S, Selker HP, Thiele H, Patel MR, Udelson JE, Ohman EM, Eitel I, Granger CB, Maehara A, Ali ZA, Ben-Yehuda O, Stone GW.Circ Cardiovasc Interv. 2021 Feb;14(2):e009879. doi: 10.1161/CIRCINTERVENTIONS.120.009879. Epub 2021 Jan 14.PMID: 33440999
A Personalized Approach to Chronic Kidney Disease and Cardiovascular Disease: JACC Review Topic of the Week. Lai AC, Bienstock SW, Sharma R, Skorecki K, Beerkens F, Samtani R, Coyle A, Kim T, Baber U, Camaj A, Power D, Fuster V, Goldman ME.
The importance of the Heart Team evaluation before transcatheter aortic valve replacement: Results from the BRAVO-3 trial.Camaj A, Claessen BE, Mehran R, Yudi MB, Power D, Baber U, Hengstenberg C, Lefevre T, Van Belle E, Giustino G, Guedeney P, Sorrentino S, Kupatt C, Webb JG, Hildick-Smith D, Hink HU, Deliargyris EN, Anthopoulos P, Sharma SK, Kini A, Sartori S, Chandrasekhar J, Dangas GD.Catheter Cardiovasc Interv. 2020 Dec;96(7):E688-E694. doi: 10.1002/ccd.28717. Epub 2020 Jan 13.PMID: 31943717
Impact of anemia on short-term outcomes after TAVR: A subgroup analysis from the BRAVO-3 randomized trial.Razuk V, Camaj A, Cao D, Nicolas J, Hengstenberg C, Sartori S, Zhang Z, Power D, Beerkens F, Chiarito M, Meneveau N, Tron C, Dumonteil N, Widder JD, Ferrari M, Violini R, Stella PR, Jeger R, Anthopoulos P, Mehran R, Dangas GD.Catheter Cardiovasc Interv. 2021 Apr 28. doi: 10.1002/ccd.29753. Online ahead of print.PMID: 33909348
Feasibility of Remote Video Assessment of Jugular Venous Pressure and Implications for Telehealth.Kelly SA, Schesing KB, Thibodeau JT, Ayers CR, Drazner MH.JAMA Cardiol. 2020 Oct 1;5(10):1194-1195. doi: 10.1001/jamacardio.2020.2339.PMID: 32609293
Anticoagulation with warfarin compared to novel oral anticoagulants for atrial fibrillation in adults with transthyretin cardiac amyloidosis: comparison of thromboembolic events and major bleeding. Mitrani LR, De Los Santos J, Driggin E, Kogan R, Helmke S, Goldsmith J, Biviano AB, Maurer MS.Amyloid. 2021 Mar;28(1):30-34. doi: 10.1080/13506129.2020.1810010. Epub 2020 Aug 19.PMID: 32814468
Pancytopenia caused by allopurinol and azathioprine interaction in a heart transplant patient: a case report. Feinman J, Rollins B, Contreras J, Parikh A.Eur Heart J Case Rep. 2020 Nov 15;4(6):1-4. doi: 10.1093/ehjcr/ytaa326. eCollection 2020 Dec.PMID: 33442614
Dihydropyridine Calcium Channel Blockers and the Risk of Severe COVID-19. Mendez SR, Frank RC, Stevenson EK, Chung M, Silverman MG.Chest. 2021 Jul;160(1):89-93. doi: 10.1016/j.chest.2021.01.073. Epub 2021 Feb 3.PMID: 33548220
Short-Term Reproducibility of Masked Hypertension Among Adults Without Office Hypertension.Cohen LP, Schwartz JE, Pugliese DN, Anstey DE, Christian JP, Jou S, Muntner P, Shimbo D, Bello NA.Hypertension. 2020 Oct;76(4):1169-1175. doi: 10.1161/HYPERTENSIONAHA.120.15287. Epub 2020 Sep 9.PMID: 32903103
Efficacy and Safety of Dual Antiplatelet Therapy After Complex PCI. Giustino G, Chieffo A, Palmerini T, Valgimigli M, Feres F, Abizaid A, Costa RA, Hong MK, Kim BK, Jang Y, Kim HS, Park KW, Gilard M, Morice MC, Sawaya F, Sardella G, Genereux P, Redfors B, Leon MB, Bhatt DL, Stone GW, Colombo A. Journal of the American College of Cardiology - October 2016
Left Main Revascularization With PCI or CABG in Patients With Chronic Kidney Disease: EXCEL Trial. Giustino G, Mehran R, Serruys PW, Sabik JF 3rd, Milojevic M, Simonton CA, Puskas JD, Kandzari DE, Morice MC, Taggart DP, Gershlick AH, Généreux P, Zhang Z, McAndrew T, Redfors B, Ragosta M 3rd, Kron IL, Dressler O, Leon MB, Pocock SJ, Ben-Yehuda O, Kappetein AP, Stone GW. Journal of the American College of Cardiology - August 2018
A Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement. Dangas GD, Tijssen JGP, Wöhrle J, Søndergaard L, Gilard M, Möllmann H, Makkar RR, Herrmann HC, Giustino G, Baldus S, De Backer O, Guimarães AHC, Gullestad L, Kini A, von Lewinski D, Mack M, Moreno R, Schäfer U, Seeger J, Tchétché D, Thomitzek K, Valgimigli M, Vranckx P, Welsh RC, Wildgoose P, Volkl AA, Zazula A, van Amsterdam RGM, Mehran R, Windecker S; GALILEO Investigators. The New England Journal of Medicine - January 2020
Lai AC, Feinman J, Oates C, Parikh A. A case report of acute heart failure and cardiogenic shock caused by catastrophic antiphospholipid syndrome and lupus myocarditis. Eur Heart J Case Rep. 2022 Nov 22
Chau VQ, Feinman J, Fullin K, Mahmood K, Oliveros E, Mitter SS, Pinney SP, Mancini DM, Lala A, Moss N. De novo human leukocyte antigen allosensitization patterns in patients bridged to heart transplantation using left ventricular assist devices. Transpl Immunol. 2022 Jun
Mitrani LR, Tumasian RA 3rd, Vilches S, De Los Santos J, Gonzalez-Lopez E, Caponetti AG, Saturi G, Mirelis JG, Longhi S, Gagliardi C, Goldsmith J, Rapezzi C, García-Pavía P, Maurer MS. Racial Differences in Atrial Fibrillation Management Between White Patients and Black Patients in Transthyretin Cardiac Amyloid. Am J Cardiol. 2023 Jan 15
Giustino G, Colombo A, Camaj A, Yasumura K, Mehran R, Stone GW, Kini A, Sharma SK. Coronary In-Stent Restenosis: JACC State-of-the-Art Review. J Am Coll Cardiol. 2022 Jul 26
Cardiology fellowship during the COVID-19 pandemic. Hadley MB, Lampert J, Zhang C. July 2020. J Am Coll Cardiol. 76 (7): 878–82
Developing a clinical approach to air pollution and cardiovascular health. Hadley, MB, Baumgartner, J and Vedanthan, R, 2018. Circulation, 137(7), pp.725-742
Different Lifestyle Interventions in Adults From Underserved Communities: The FAMILIA Trial. Rodrigo Fernandez-Jimenez, Risa Jaslow, Sameer Bansilal, Raquel Diaz-Munoz, Monali Fatterpekar, Maribel Santana, Andrea Clarke-Littman, Jacqueline Latina, Ana V. Soto, Christopher A. Hill, Mohamed Al-Kazaz, Rajeev Samtani, Rajesh Vedanthan, Chiara Giannarelli, Jason C. Kovacic, Emilia Bagiella, Andrew Kasarskis, Zahi A. Fayad and Valentin Fuster. J Am Coll Cardiol. 2020;75(1):42-56. doi:10.1016/j.jacc.2019.10.021
Effect of stent diameter in women undergoing percutaneous coronary intervention with early- and new-generation drug-eluting stents: From the WIN-DES collaboration. Camaj A, Giustino G, Claessen BE. Int J Cardiol. 2019 Jul 15;287:59-61.
Temporal Trends in Statin Prescriptions and Residual Cholesterol Risk in Patients With Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. Guedeney P, Claessen BE, Baber U, Camaj A, et al. Am J Cardiol. 2019;123(11):1788-1795. doi:10.1016/j.amjcard.2019.03.005.
Different Lifestyle Interventions in Adults From Underserved Communities: The FAMILIA Trial. Fernandez-Jimenez R, Jaslow R, Bansilal S, Samtani R., et al. J Am Coll Cardiol. 2020;75(1):42-56. doi:10.1016/j.jacc.2019.10.021
Characterization of Myocardial Injury in Patients With COVID-19. Giustino G, Croft LB, Stefanini GG, Bragato R, Silbiger JJ, Vicenzi M, Danilov T, Kukar N, Shaban N, Kini A, Camaj A, Bienstock SW, Rashed ER, Rahman K, Oates CP, Buckley S, Elbaum LS, Arkonac D, Fiter R, Singh R, Li E, Razuk V, Robinson SE, Miller M, Bier B, Donghi V, Pisaniello M, Mantovani R, Pinto G, Rota I, Baggio S, Chiarito M, Fazzari F, Cusmano I, Curzi M, Ro R, Malick W, Kamran M, Kohli-Seth R, Bassily-Marcus AM, Neibart E, Serrao G, Perk G, Mancini D, Reddy VY, Pinney SP, Dangas G, Blasi F, Sharma SK, Mehran R, Condorelli G, Stone GW, Fuster V, Lerakis S, Goldman ME. J Am Coll Cardiol. 2020 Nov 3;76(18):2043-2055. doi: 10.1016/j.jacc.2020.08.069. PMID: 33121710; PMCID: PMC7588179.
Impact of percutaneous closure device type on vascular and bleeding complications after TAVR: A post hoc analysis from the BRAVO-3 randomized trial. Power D, Schäfer U, Guedeney P, et al. Catheter Cardiovasc Interv. 2019;93(7):1374-1381. doi:10.1002/ccd.28295
Cardiovascular Complications of Interatrial Conduction Block: JACC State-of-the-Art Review. Power DA, Lampert J, Camaj A, Bienstock SW, Kocovic N, Bayes-Genis A, Miller MA, Bayés-de-Luna A, Fuster V. J Am Coll Cardiol. 2022 Mar 29;79(12):1199-1211. doi: 10.1016/j.jacc.2022.01.030. PMID: 35331415.
Left Ventricular Thrombus Following Acute Myocardial Infarction: JACC State-of-the-Art Review. Camaj A, Fuster V, Giustino G, Bienstock SW, Sternheim D, Mehran R, Dangas GD, Kini A, Sharma SK, Halperin J, Dweck MR, Goldman ME. J Am Coll Cardiol. 2022 Mar 15;79(10):1010-1022. doi: 10.1016/j.jacc.2022.01.011. PMID: 35272796.
Impact of Myocardial Injury in Hospitalized Patients With COVID-19 in 2 Peak Time Periods. Bienstock SW, Tandon P, Govindarajulu U, Leibner E, Glicksberg BS, Samtani R, Giustino G, Gidwani U, Kohli-Seth R, Goldman ME. J Am Coll Cardiol. 2021 Oct 5;78(14):1482-1483. doi: 10.1016/j.jacc.2021.08.005. PMID: 34593130; PMCID: PMC8475637.
Echocardiography in the time of Covid-19: Ultrasound enhancing agents save time and augment diagnostic information. Sperling D, Lai AC, Bienstock SW, Samtani R, Beerkens F, Satish M, Pulaski M, Edens M, Oates C, Kocovic N, Buckley S, Giustino G, Lerakis S, Liao S, Stern E, Croft LB, Goldman ME. Int J Cardiol. 2022 Jan 1;346:100-102. doi: 10.1016/j.ijcard.2021.11.040. Epub 2021 Nov 16.
Assessment and validation of a novel fast fully automated artificial intelligence left ventricular ejection fraction quantification software.. Samtani R, Bienstock SW, Lai AC, Liao S, Baber U, Croft L, Stern E, Beerkens F, Ting P, Goldman ME. Echocardiography. 2022 Mar;39(3):473-482. doi: 10.1111/echo.15318. Epub 2022 Feb 17
Using Clinical and Echocardiographic Characteristics to Characterize the Risk of Ischemic Stroke in Patients with COVID-19. Oates CP, Bienstock SW, Miller M, Giustino G, Danilov T, Kukar N, Kocovic N, Sperling D, Singh R, Benhuri D, Beerkens F, Camaj A, Lerakis S, Croft L, Stein LK, Goldman ME. J Stroke Cerebrovasc Dis. 2022 Feb;31(2):106217. doi: 10.1016/j.jstrokecerebrovasdis.2021.106217. Epub 2021 Nov 8. PMID: 34826678; PMCID: PMC8572704.
Acute Type A Aortic Dissection After TAVR in an Octogenarian With Ascending Aorta Aneurysm. Hashemi H, Khera S, Anastasius M, Ismail El-Hamamsy, Tang GHL, Sharma SK, Kini A, Lerakis S. JACC Cardiovasc Interv. 2022 Jan 24;15(2):220-222. doi: 10.1016/j.jcin.2021.10.021. Epub 2021 Dec 29. PMID: 34973906.
Systemic Embolism in Amyloid Transthyretin Cardiomyopathy. Vilches S, Fontana M, Gonzalez-Lopez E, Mitrani L, Saturi G, Renju M, Griffin JM, Caponetti A, Gnanasampanthan S, De Los Santos J, Gagliardi C, Rivas A, Dominguez F, Longhi S, Rapezzi C, Maurer MS, Gillmore J, Garcia-Pavia P. Eur J Heart Fail. 2022 Jun 1. doi: 10.1002/ejhf.2566. Epub ahead of print. PMID: 35650018.
Risk factor management of atrial fibrillation using mHealth: The Atrial Fibrillation - Helping Address Care with Remote Technology (AF-HEART) Pilot Study. Mitrani LR, Goldenthal I, Leskowitz J, Wan EY, Dizon J, Saluja D, Creber RM, Turchioe MR, Sciacca RR, Garan H, Hickey KT, Korner J, Biviano AB. Cardiovasc Digit Health J. 2021 Nov 24;3(1):14-20. doi: 10.1016/j.cvdhj.2021.11.003. PMID: 35265931; PMCID: PMC8890079.
Myocardial Bridging: Diagnosis, Functional Assessment, and Management: JACC State-of-the-Art Review. Sternheim D, Power DA, Samtani R, Kini A, Fuster V, Sharma S. J Am Coll Cardiol. 2021 Nov 30;78(22):2196-2212. doi: 10.1016/j.jacc.2021.09.859. PMID: 34823663.
Coronary Dissection and Right Heart Failure Salvaged by PCI With Percutaneous Intraluminal Microaxial RV-Assist Support. Beerkens FJ, Power D, Razuk V, Kocovic N, Omar A, Mtisi T, Serrao G, Khera S, Dangas G. JACC Case Rep. 2021 Oct 20;3(14):1612-1616. doi: 10.1016/j.jaccas.2021.06.044. PMID: 34729513; PMCID: PMC8543164.
